Recent publications

Authors: G. Longo; M. Montévil
Journal Article, In Press
Authors: M. Montévil
Journal Article, 2017
Authors: M. Montévil; M. Bizzarri
Book Chapter, In Press
Authors: M. Montévil; M. Mossio; M. Silberstein
Book Chapter, 2017
Authors: M. Montévil; G. Longo; A. Soto; T. Gaudin; D. Lacroix; M.C. Maurel; J.C. Pomerol
Book Chapter, 2017

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The biological default state of cell proliferation with variation and motility, a fundamental principle for a theory of organisms

TitleThe biological default state of cell proliferation with variation and motility, a fundamental principle for a theory of organisms
Publication TypeJournal Article
Year of Publication2016
AuthorsSoto, AM, Longo, G, Montévil, M, Sonnenschein, C
JournalProgress in Biophysics and Molecular Biology
Pagination-
ISSN0079-6107
AbstractThe principle of inertia is central to the modern scientific revolution. By postulating this principle Galileo at once identified a pertinent physical observable (momentum) and a conservation law (momentum conservation). He then could scientifically analyze what modifies inertial movement: gravitation and friction. Inertia, the default state in mechanics, represented a major theoretical commitment: there is no need to explain uniform rectilinear motion, rather, there is a need to explain departures from it. By analogy, we propose a biological default state of proliferation with variation and motility. From this theoretical commitment, what requires explanation is proliferative quiescence, lack of variation, lack of movement. That proliferation is the default state is axiomatic for biologists studying unicellular organisms. Moreover, it is implied in Darwin's “descent with modification”. Although a “default state” is a theoretical construct and a limit case that does not need to be instantiated, conditions that closely resemble unrestrained cell proliferation are readily obtained experimentally. We will illustrate theoretical and experimental consequences of applying and of ignoring this principle.
URLhttp://www.sciencedirect.com/science/article/pii/S0079610716300785
DOI10.1016/j.pbiomolbio.2016.06.006
Citation KeySoto2016
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