Recent publications

Authors: M. Montévil; M. Bizzarri
Book Chapter, In Press
Authors: M. Montévil; M. Mossio; M. Silberstein
Book Chapter, 2017
Authors: M. Montévil; G. Longo; A. Soto; T. Gaudin; D. Lacroix; M.C. Maurel; J.C. Pomerol
Book Chapter, In Press
Authors: G. Longo; M. Montévil; T. Gaudin; D. Lacroix; M.C. Maurel; J.C. Pomerol
Book Chapter, In Press
Authors: M. Montévil; C. Sonnenschein; A.M. Soto
Journal Article, 2016

Maël Montévil's research page

Investigations in theoretical biology

Videos: Modeling mammary organogenesis from biological first principles: cells and their physical constraints.

Montévil, M., Speroni, L., Sonnenschein, C., & Soto, A. M.. (2016). Modeling mammary organogenesis from biological first principles: Cells and their physical constraints. Progress in Biophysics and Molecular Biology, -. doi:10.1016/j.pbiomolbio.2016.08.004

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

  • Video 1. Projections of breast epithelial cells seeded in a fibrilar matrix.

    Cells emit projections in all directions soon after seeding. These cell projections are involved in collagen organization.
  • Video 2. Breast epithelial cells forming an acinus in a non-fibrilar matrix at day 4.

    Cells display limited motility and emit only short projections into the matrix. Cells rotate and divide resulting in the formation of an acinus, a sphere with a central lumen.
  • Video 3. Branching duct at day 7 of culture.

    A cell detaches from the main structure and is incorporated back into the structure.
  • Video 4. Collagen fibers and breast epithelial structures after 6 days in culture.

    Cells organize collagen in a collagen only matrix and the collagen bundles (green) facilitate the merging of epithelial structures.
  • Video 5 and 6. Formation of a duct by the mathematical model.

    Cells are represented in green and the ductal lumen in orange in 3 dimensions. Cells organize collagen over time by exerting forces; in turn, collagen constrains cell proliferation and motility. These interactions lead to the emergence of a main direction of growth.
  • Video 7 and 8. Formation of branching ducts by the mathematical model.

    Cells are represented in green and the ductal lumen in orange in 3 dimensions. Ducts branch spontaneously in our model (see also the end of video 5 and 6). For these simulations, we reduced the range of the inhibitor which increases the odds of branching.
  • Video 9. Formation of an acinus by the mathematical model.

    Cells are represented in green and the lumen in orange in 3 dimensions. Here, the interactions between the ECM and the cells were removed in order to mimic the effect of Matrigel. In this condition, cells proliferate and move in an isotropic manner leading to the formation of a rounded structure.
Undefined