Recent publications

Authors: M. Montévil; M. Bizzarri
Book Chapter, In Press
Authors: M. Montévil; M. Mossio; M. Silberstein
Book Chapter, 2017
Authors: M. Montévil; G. Longo; A. Soto; T. Gaudin; D. Lacroix; M.C. Maurel; J.C. Pomerol
Book Chapter, In Press
Authors: G. Longo; M. Montévil; T. Gaudin; D. Lacroix; M.C. Maurel; J.C. Pomerol
Book Chapter, In Press
Authors: M. Montévil; C. Sonnenschein; A.M. Soto
Journal Article, 2016

Maël Montévil's research page

Investigations in theoretical biology

Theoretical approach of ductal morphogenesis

TitleTheoretical approach of ductal morphogenesis
Publication TypeJournal Article
Year of Publication2016
AuthorsMontévil, M, Sonnenschein, C, Soto, AM
JournalJournal of Theoretical and Applied Vascular Research
Volume1
Issue1
Date Published11/2016
AbstractWe developed 3D culture methods that reproduce in vitro mammary gland ductal morphogenesis. We are proposing a conceptual framework to understand morphogenetic events based on epistemologically sound biological principles instead of the common practice of using only physical principles. More specifically, our theoretical framework is based on the principle that the default state of cells is proliferation with variation and motility. We emphasize the role played by the agency of cells embedded in a gel and the circularity that is relevant for the intended process, whereby cells act upon other cells and on matrix elements, and are subject to the agentivity of neighboring cells. This circularity strongly differs from classical linear causality. Finally, our approach opens up the study of causal determination to multilevel explanations rather than to reductive ones involving only molecules in general and genes in particular.
URLhttp://www.vasculab.eu/jtavr/jtavr01/jtavr011/JTAVR000007-MontevilM/JTAVR000007-MontevilM.htm
DOI10.24019/jtavr.7
Citation Key11/2016